Biopharm Services

News from BPS


Feb 2012: New Technology Grant

1 FEB 2011: Biopharm Services has been awarded a UK Technology Strategy Board grant to develop our software bioprocess database application to support rapid bioprocess development and technology transfer to manufacturing. Extending the functionality of the BioSolve platform to recipe management and facility fit.


New Newsletter published

New Newsletter published October 2011. Gives details of the exciting changes happening with the BioSolve Suite.


Annual Bioprocess Simulation prize

Biopharm Service's Annual Bioprocess Simulation prize was awarded in November 2011 to a team of undergraduate students at UCL's Department of Biochemical Engineering for their work on "Application of BioSolve computer simulation tool for investigating the process economics of antibody production". The BioSolve modelling tool was used to evaluate the economics of a process to produce an IgG antibody for treating arthritis and to understand impact of scale-up to and for process optimisation. This demonstrates the value of BioSolve to help students within the teaching programmes at UCL to understand the impact of process and technology choices.
Download the UCL BioSolve poster


Past President of the IChemE joins the Biopharm Team

Bioprocess specialist Stephen Vranch joins Biopharm Services. Since 1968 Stephen has held senior positions in Project and Process Engineering, Fermentation and Process Development and in Production of Diagnostics and Biological Therapeutic Pharmaceuticals, including licensed bulk product. Stephen was a former President of the IChemE. As our lead consultant, Stephen specialises on all aspects of CGMP regulatory compliance.


BioSolve

BioSolve used to generate data for GE lifecycle assessment of the entire monocloncal antibody production process: a comparison of multi-use and single-use processes. Upcoming webinar

Adoption of BioSolve Process in UCL Biochemical Engineering Courses

BioPharm Services is pleased to announce the adoption of BioSolve Process by the Biochemical Engineering Department of University College London (UCL). The cost modelling software has been used for both undergraduate and postgraduate courses including the MBI® programme (Modular Training for the Bioprocess Industries). MORE »



CLIENT FEEDBACK

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Biopharm Software Services

Promedior Inc Feedback

'BioSolve is an excellent tool for planning early stage process development alternatives.'

'BioSolve provides a quantitative edge when presenting proposed directions to investors.'

'BioSolve enables us to focus on potential process bottlenecks in terms of cost or throughput.'

Scott Willett, Director biopharmaceutical development, Promedior Inc

Dow Pharmaceuticals Feedback

'One hidden benefit of BioSolve is that it is comes populated with an enormous wealth of historical industry data and this allows us to benchmark Pfēnex Expression Technology's performance more accurately than we would be able to do with internal data alone.

'This enables us to better articulate the key Cost of Goods advantages realized by our clients'

Patrick Lucy, Global Business Development Leader, Pfēnex Inc, Dow Pharmaceuticals

Xcellerex Inc Feedback

'BioSolve has been a very useful tool for demonstrating to our prospective customers the benefit of disposables and the FlexFactory platform.'

'One hidden benefit of BioSolve is that it is comes populated with an enormous wealth of historical industry data and this allows us to benchmark more accurately than we would be able to do with internal data alone.'

'We use BioSolve with prospective customers to plug their specific numbers into the model. All the data and assumptions are clearly presented for review and discussion. The Excel format and preset templates allows BioSolve to be reconfigured quickly and easily at a high level or manipulated at a very detailed level, depending upon the needs and sophistication of the user.'

Geoff Hodge, Managing Director - Technology, Xcellerex Inc.

Sanofi Pasteur Feedback

'Validating investment scenarios is a key part of developing our business strategy and is used to set priorities. With BioSolve, what used to take months now can be evaluated in a day! We were amazed recently when on a particular case we were able to generate comparable and coherent results in a day that did take us months manually to prepare. Not only does this save a lot of time it helps us to carry out sensitivity and 'what if' scenario analyses with BioSolve, this supports better informed decision making.'

Jean-Marc Guillaume, Head of cell culture and virology, Sanofi Pasteur vaccines

Avecia Biologics Feedback

'BPS models provide Insight into the complexities of biotech plants, It helps to set Direction in projects and improvement programmes'

Bruce Williams Avecia Biologics

Millipore Feedback

'It is important for the customer to select the right mix of Mobius® single-use solutions to optimize their manufacturing process and maximize the return on investment. BioSolve, an industry wide popular modeling package allows the customers to map their process and develop cost of ownership models'.

Vikas Gupta, Group Product Manager, Advanced Manufacturing Solutions, Millipore corporation

Case Studies

Click a title to download the document in PDF or Word format.

BioSolve

Professor Nigel Titchener Hooker, University College London: Upskilling bioprocess engineers

Linking BioSolve to ultrascaledown

Jean-Marc Guillaume, Bioprocessing R&D, Sanofi Pasteur

'Developing business cases for new products, new technologies'

iCELLis Economical Impact on Investment and Production Costs

An economic model based comparison of Artelis' iCELLis™ technology with traditional stainless steel bioreactors used for mAb production.

Economic Model Guiding Expression System Choices in Early Phase Clinical Development

Cost modelling applied early in the development phase to quantitatively compare expression system options and identify potential design issues.

Evaluation of Disposables Using BioSolve

An assessment of single-use disposables technologies carried out for a confidential client.

Improving Yield and Throughput of Downstream Processing: Biomass Removal & Capture Steps

Quantification of process improvements on economic, yield, throughput and footprint bases using Upfront's process technologies.

Pfenex - The New Standard For Protein Expression

An analysis of how the Dow Pharmaceuticals Pfenex expression system can address speed, quality and cost of goods issues relating to process performance.

Using Disposables in an Antibody Production Process

A cost-effectiveness study of technology transfer between two production sites.

FlexFactory - The Economic and Strategic Value of Flexible Manufacturing Capacity

The advantages of single-use systems and Xcellerex's FlexFactory flexible manufacturing system.

Economic Feasibility Study

The objective of the project is to evaluate the economic feasibility of different bioprocess options for the production of rhSAP.


BioSim

Capacity Utilization for Process Development Scheduling

A simulation model used to predict available capacity for Xoma's clinical pipeline included integrated pilot plant and GMP manufacturing facility models.

Optimising Design for Mammalian Cell Culture

An overview of how simulation was used to optimise a conceptual design for a new mammalian cell culture facility.

Optimization of Manufacturing Operations Using Discrete Event Simulation

The role of simulation in the operation of a contract manufacturing facility operation by Avecia Biologics.

Avecia Biologics

Long term modelling support for a contract manufacturing facility incorporating multi-products and all aspects of the operations.

Bayer Healthcare

Debottlenecking and long term capacity planning for an existing diagnostics assay kit manufacturing facility.