Case Study 5 - Logistics

Analysis of production plans and scheduling requirements for an existing recombinant protein purification line. The project objectives were to determine capacity and scheduling constraints, and develop a feasible production plan based on personnel and equipment availability. Comparison of the model predictions and actual process activities indicated a discrepancy, with predicted WFI usage lower than recorded rates. The difference was determined to be due to incorrect operational procedures controlling the use of WFI for CIP that resulted in the diversion of WFI direct to waste.

Aims & Objectives Capacity prediction Process scheduling, incl. buffer preparation CIP skid usage Labour/shift requirements Utility usage prediction