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Chapter 2: Road to Process Model Evolution

Chapter 2: Road to Process Model Evolution

Landmark on 2nd June in London


On the second day of the User Group Forum, attendees were welcomed back after a lively and enjoyable networking dinner at a Local Upscale Chinese restaurant. The day began with a keynote speech delivered by Professor Richard Allmendinger from the University of Manchester, who addressed the topic of “Resource Constrained Optimization in Drug Development”. The keynote speech was a hit among attendees, who were fascinated to learn about the distinctions between Machine Learning and Artificial Intelligence. Richard described various types of AI, which sparked much discussion amongst the audience. Many attendees were left pondering the regulation of AI use and application and the future implications of an emotional AI. The moral and ethical implications of such advancements were also considered, with many people recalling “Do Androids Dream of Electric Sheep?”, a famous novel by Philip K. Dick adapted into the film Bladerunner. As with any new technology, opportunities come with challenges to overcome.

Andrew Sinclair - BioSolve Analytics and Optimizer

Next up on the agenda was Yuki, who briefly explored the current product offerings, including BioSolve-Analytics and Optimiser. Attendees were given a glimpse into the new platform, and some vision for the future was shared by our Managing Director/Founder, Andrew Sinclair, who went into greater detail about future development plans. More information on this topic and the results from the Workshop will be provided in Chapter 3 of the blog.

After the break, Niklas Jungnelius from Cytiva delivered a thought-provoking talk on Buffer Management strategies to improve process economy and environmental sustainability. Media and Buffer Management in the facility were deemed critical topics to be discussed, and the importance of Inline Dilution and Inline Conditioning in changing the outcome compared to traditional methodologies was intriguing. Following this, Joris Van de Velde from 3M delivered another great talk before lunch.

After lunch, Aditi Holey showcased the Optimiser case study, demonstrating how it can be used to find the optimal solution around Protein A chromatography configurations. Several attendees expressed interest in obtaining the package to conduct their cases.

We were delighted to have Hiren Ardeshna from GSK join us online for a vital talk on “Use of BioSolve Application for Facility Fit Analysis”, which was delivered clearly via web meeting. His presence was felt even though he was not physically present in the room, and an audience member considered the talk one of the day’s highlights. Felix Dieringer from Takeda then gave a fantastic presentation on using BioSolve Process to assess the environmental impact of biopharmaceuticals. There are many possibilities for expanding on this area in the future, leaving attendees with much to ponder.

Chapter 3 of the blog will revisit Andrew’s “Roadmap for BioSolve” talk and share some fascinating insights from our user communities during the last Open Forum Workshop. To conclude this chapter, we quote the feedback of Alexa Kopf from BDO, who said, This was a wonderful and thoughtfully planned event! I’ve shared my positive experience with my team and am excited to see what the future brings.