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Antibody Drug Conjugates
Antibody Drug Conjugates aren’t “too expensive” – how can the costs of manufacture be monitored and improved?

Antibody Drug Conjugates aren’t “too expensive” – how can the costs of manufacture be monitored and improved?

The historical development of antibody drug conjugates is a well told yarn, where self-immolating reactions are scribbled on ESACT conference paper with PEGS free-issue pens. These multidisciplinary scientists and the molecules they make are writing a new storyline now. Increased activity With six approvals of

Regeneron’s High Profile Success? Demand for COVID-19 prophylactics – what role for Pichia expression technology to assist access

Regeneron’s High Profile Success? Demand for COVID-19 prophylactics – what role for Pichia expression technology to assist access

With Regeneron’s high profile, single-person, single-site, clinical trial proving successful (along with much supporting other clinical data!), will neutralising antibodies surf the second wave? Our COVID-related blogs focus on capacity and cost of making the treatments and understanding opportunities or bottlenecks in large scale provision

The Top-Level Value of N-1 Perfusion Processes for 100-1000kg/yr Biologics Manufacture

The Top-Level Value of N-1 Perfusion Processes for 100-1000kg/yr Biologics Manufacture

Are you interested in optimising performance of your upstream biologics manufacturing? Cell retention/media perfusion devices increase the viable cell density of bioreactors and can be used to reduce the number or volume of seeding stages of the production bioreactor (1,2,3). Additionally, the production cycle can

COVID-19 Adenovirus-Based Vaccine Supply – Production Titre & Dosage Quantity will be Critical to Achieve Global Access

COVID-19 Adenovirus-Based Vaccine Supply – Production Titre & Dosage Quantity will be Critical to Achieve Global Access

A Case Study based on the Covid-19 vaccine being developed by the Jenner Institute, Oxford University. An affordable, global vaccine for Covid-19 is still seen as the best chance of protecting vulnerable people and populations at the same time as getting everyone back to normal

Anti-COVID-19 Biologics – Using the BioPhorum Standard MAb Process to Estimate Required Manufacturing Infrastructure, Investment and Resulting Drug Cost

Anti-COVID-19 Biologics – Using the BioPhorum Standard MAb Process to Estimate Required Manufacturing Infrastructure, Investment and Resulting Drug Cost

The biopharmaceutical industry is investigating various biologics as treatments for COVID-19. This blog looks at the scale of global manufacturing that may be required and the associated cost of goods of these drug products for COVID-19. Vaccine manufacturing will be discussed in a separate blog.

The Fast Optimisation of BioSolve Process Modelling with Bayesian Optimisation

The Fast Optimisation of BioSolve Process Modelling with Bayesian Optimisation

Biopharmaceutical manufacturing capacity, efficiency, flexibility and economics are all important outputs for organisations to optimize and continuously review. BioSolve Process is the biopharmaceutical industry’s most powerful software for bioprocess analysis. Due to the complexity of therapeutic manufacturing there are many variables contributing to the overall